AutomedicationFrancoV1, Main, Exploration, bibRecord, 000754

The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.

Identifieur interne : 000754 ( Main/Exploration ); précédent : 000753; suivant : 000755

The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.

Auteurs : Simone Birnbaum [France] ; Jean-Yves Hogrel [France] ; Raphael Porcher [France] ; Pierre Portero [France] ; Bernard Clair [France] ; Bruno Eymard [France] ; Sophie Demeret [France] ; Guillaume Bassez [France] ; Marcela Gargiulo [France] ; Estelle Louët [France] ; Sonia Berrih-Aknin [France] ; Asmaa Jobic [France] ; Philippe Aegerter [France] ; Philippe Thoumie [France] ; Tarek Sharshar [France]

Source :

Trials [ 1745-6215 ] ; 2018.

RBID : pubmed:29347991

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Aptitude physique (MeSH), Essais contrôlés randomisés comme sujet (MeSH), Facteurs temps (MeSH), Femelle (MeSH), France (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mesures des résultats rapportés par les patients (MeSH), Muscles squelettiques (physiopathologie), Myasthénie (diagnostic), Myasthénie (physiopathologie), Myasthénie (thérapie), Mâle (MeSH), Méthode en simple aveugle (MeSH), Qualité de vie (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Tolérance à l'effort (MeSH), Traitement par les exercices physiques (effets indésirables), Traitement par les exercices physiques (méthodes), État de santé (MeSH), Études multicentriques comme sujet (MeSH).
MESH :
- diagnostic : Myasthénie.
- effets indésirables : Traitement par les exercices physiques.
- méthodes : Traitement par les exercices physiques.
- physiopathologie : Muscles squelettiques, Myasthénie.
- thérapie : Myasthénie.
- Adolescent, Adulte, Adulte d'âge moyen, Aptitude physique, Essais contrôlés randomisés comme sujet, Facteurs temps, Femelle, France, Humains, Jeune adulte, Mesures des résultats rapportés par les patients, Mâle, Méthode en simple aveugle, Qualité de vie, Résultat thérapeutique, Sujet âgé, Tolérance à l'effort, État de santé, Études multicentriques comme sujet.
Wicri :
- geographic : France.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Exercise Therapy (adverse effects), Exercise Therapy (methods), Exercise Tolerance (MeSH), Female (MeSH), France (MeSH), Health Status (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Multicenter Studies as Topic (MeSH), Muscle, Skeletal (physiopathology), Myasthenia Gravis (diagnosis), Myasthenia Gravis (physiopathology), Myasthenia Gravis (therapy), Patient Reported Outcome Measures (MeSH), Physical Fitness (MeSH), Quality of Life (MeSH), Randomized Controlled Trials as Topic (MeSH), Single-Blind Method (MeSH), Time Factors (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
MESH :
- geographic : France.
- adverse effects : Exercise Therapy.
- diagnosis : Myasthenia Gravis.
- methods : Exercise Therapy.
- physiopathology : Muscle, Skeletal, Myasthenia Gravis.
- therapy : Myasthenia Gravis.
- Adolescent, Adult, Aged, Exercise Tolerance, Female, Health Status, Humans, Male, Middle Aged, Multicenter Studies as Topic, Patient Reported Outcome Measures, Physical Fitness, Quality of Life, Randomized Controlled Trials as Topic, Single-Blind Method, Time Factors, Treatment Outcome, Young Adult.

Abstract

BACKGROUND

Research exploring the effects of physical exercise in auto-immune myasthenia gravis (MG) is scarce. The few existing studies present methodological shortcomings limiting the conclusions and generalisability of results. It is hypothesised that exercise could have positive physical, psychological as well as immunomodulatory effects and may be a beneficial addition to current pharmacological management of this chronic disease. The aim of this study is to evaluate the benefits on perceived quality of life (QOL) and physical fitness of a home-based physical exercise program compared to usual care, for patients with stabilised, generalised auto-immune MG.

METHODS

MGEX is a multi-centre, interventional, randomised, single-blind, two-arm parallel group, controlled trial. Forty-two patients will be recruited, aged 18-70 years. Following a three-month observation period, patients will be randomised into a control or experimental group. The experimental group will undertake a 40-min home-based physical exercise program using a rowing machine, three times a week for three months, as an add-on to usual care. The control group will receive usual care with no additional treatment. All patients will be followed up for a further three months. The primary outcome is the mean change in MGQOL-15-F score between three and six months (i.e. pre-intervention and immediately post-intervention periods). The MGQOL-15-F is an MG-specific patient-reported QOL questionnaire. Secondary outcomes include the evaluation of deficits and functional limitations via MG-specific clinical scores (Myasthenia Muscle Score and MG-Activities of Daily Living scale), muscle force and fatigue, respiratory function, free-living physical activity as well as evaluations of anxiety, depression, self-esteem and overall QOL with the WHO-QOL BREF questionnaire. Exercise workload will be assessed as well as multiple safety measures (ECG, biological markers, medication type and dosage and any disease exacerbation or crisis).

DISCUSSION

This is the largest randomised controlled trial to date evaluating the benefits and tolerance of physical exercise in this patient population. The comprehensive evaluations using standardised outcome measures should provide much awaited information for both patients and the scientific community. This study is ongoing.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT02066519 . Registered on 13 January 2014.

DOI: 10.1186/s13063-017-2433-2
PubMed: 29347991
PubMed Central: PMC5774148

Affiliations:

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Le document en format XML

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<affiliation wicri:level="3"><nlm:affiliation>Department of Histopathology and Animal Models, Institut Pasteur, Paris, France. tsharshar@gmail.com.</nlm:affiliation>
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<affiliation wicri:level="3"><nlm:affiliation>Rothschild Hospital, AP-HP, Paris, France.</nlm:affiliation>
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<author><name sortKey="Eymard, Bruno" sort="Eymard, Bruno" uniqKey="Eymard B" first="Bruno" last="Eymard">Bruno Eymard</name>
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<wicri:regionArea>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea>
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<author><name sortKey="Demeret, Sophie" sort="Demeret, Sophie" uniqKey="Demeret S" first="Sophie" last="Demeret">Sophie Demeret</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Neurological Intensive Care Unit, Pitié-Salpêtrière Hospital, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Bassez, Guillaume" sort="Bassez, Guillaume" uniqKey="Bassez G" first="Guillaume" last="Bassez">Guillaume Bassez</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Gargiulo, Marcela" sort="Gargiulo, Marcela" uniqKey="Gargiulo M" first="Marcela" last="Gargiulo">Marcela Gargiulo</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<affiliation wicri:level="3"><nlm:affiliation>Laboratory of Clinical Psychology, Psychopathology, and Psychoanalysis (EA 4056) Paris Descartes University - Sorbonne Paris Cité, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Louet, Estelle" sort="Louet, Estelle" uniqKey="Louet E" first="Estelle" last="Louët">Estelle Louët</name>
<affiliation wicri:level="3"><nlm:affiliation>Laboratory of Clinical Psychology, Psychopathology, and Psychoanalysis (EA 4056) Paris Descartes University - Sorbonne Paris Cité, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory of Clinical Psychology, Psychopathology, and Psychoanalysis (EA 4056) Paris Descartes University - Sorbonne Paris Cité, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
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<author><name sortKey="Berrih Aknin, Sonia" sort="Berrih Aknin, Sonia" uniqKey="Berrih Aknin S" first="Sonia" last="Berrih-Aknin">Sonia Berrih-Aknin</name>
<affiliation wicri:level="3"><nlm:affiliation>UMRS 974 UPMC, INSERM, FRE 3617 CNRS, AIM, Centre of Research in Myology, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UMRS 974 UPMC, INSERM, FRE 3617 CNRS, AIM, Centre of Research in Myology, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Jobic, Asmaa" sort="Jobic, Asmaa" uniqKey="Jobic A" first="Asmaa" last="Jobic">Asmaa Jobic</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche Clinique Paris ÎIle- de- France Ouest (URCPO), Ambroise Paré Hospital, Boulogne Billancourt, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche Clinique Paris ÎIle- de- France Ouest (URCPO), Ambroise Paré Hospital, Boulogne Billancourt</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Boulogne-Billancourt</settlement>
</placeName>
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<affiliation wicri:level="1"><nlm:affiliation>Raymond Poincaré Hospital, AP-HP, Garches, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Raymond Poincaré Hospital, AP-HP, Garches</wicri:regionArea>
<wicri:noRegion>Garches</wicri:noRegion>
<wicri:noRegion>Garches</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aegerter, Philippe" sort="Aegerter, Philippe" uniqKey="Aegerter P" first="Philippe" last="Aegerter">Philippe Aegerter</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche Clinique Paris ÎIle- de- France Ouest (URCPO), Ambroise Paré Hospital, Boulogne Billancourt, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche Clinique Paris ÎIle- de- France Ouest (URCPO), Ambroise Paré Hospital, Boulogne Billancourt</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Boulogne-Billancourt</settlement>
</placeName>
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<affiliation wicri:level="1"><nlm:affiliation>Raymond Poincaré Hospital, AP-HP, Garches, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Raymond Poincaré Hospital, AP-HP, Garches</wicri:regionArea>
<wicri:noRegion>Garches</wicri:noRegion>
<wicri:noRegion>Garches</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>UVSQ, UMR-S 1168, Université Versailles St-Quentin-en-Yvelines, Versailles</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Versailles</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, U1168 VIMA, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1168 VIMA, Villejuif</wicri:regionArea>
<placeName><settlement type="city">Villejuif</settlement>
</placeName>
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<author><name sortKey="Thoumie, Philippe" sort="Thoumie, Philippe" uniqKey="Thoumie P" first="Philippe" last="Thoumie">Philippe Thoumie</name>
<affiliation wicri:level="3"><nlm:affiliation>Rothschild Hospital, AP-HP, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Rothschild Hospital, AP-HP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Raymond Poincaré Hospital, AP-HP, Garches, France. tsharshar@gmail.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Intensive Care Unit, Raymond Poincaré Hospital, AP-HP, Garches</wicri:regionArea>
<wicri:noRegion>Garches</wicri:noRegion>
<wicri:noRegion>Garches</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Versailles, Saint-Quentin-en-Yvelines, France. tsharshar@gmail.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Versailles, Saint-Quentin-en-Yvelines</wicri:regionArea>
<wicri:noRegion>Saint-Quentin-en-Yvelines</wicri:noRegion>
<wicri:noRegion>Saint-Quentin-en-Yvelines</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Department of Histopathology and Animal Models, Institut Pasteur, Paris, France. tsharshar@gmail.com.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Histopathology and Animal Models, Institut Pasteur, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<series><title level="j">Trials</title>
<idno type="eISSN">1745-6215</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Exercise Therapy (adverse effects)</term>
<term>Exercise Therapy (methods)</term>
<term>Exercise Tolerance (MeSH)</term>
<term>Female (MeSH)</term>
<term>France (MeSH)</term>
<term>Health Status (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multicenter Studies as Topic (MeSH)</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Myasthenia Gravis (diagnosis)</term>
<term>Myasthenia Gravis (physiopathology)</term>
<term>Myasthenia Gravis (therapy)</term>
<term>Patient Reported Outcome Measures (MeSH)</term>
<term>Physical Fitness (MeSH)</term>
<term>Quality of Life (MeSH)</term>
<term>Randomized Controlled Trials as Topic (MeSH)</term>
<term>Single-Blind Method (MeSH)</term>
<term>Time Factors (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Young Adult (MeSH)</term>
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<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Aptitude physique (MeSH)</term>
<term>Essais contrôlés randomisés comme sujet (MeSH)</term>
<term>Facteurs temps (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>France (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mesures des résultats rapportés par les patients (MeSH)</term>
<term>Muscles squelettiques (physiopathologie)</term>
<term>Myasthénie (diagnostic)</term>
<term>Myasthénie (physiopathologie)</term>
<term>Myasthénie (thérapie)</term>
<term>Mâle (MeSH)</term>
<term>Méthode en simple aveugle (MeSH)</term>
<term>Qualité de vie (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Tolérance à l'effort (MeSH)</term>
<term>Traitement par les exercices physiques (effets indésirables)</term>
<term>Traitement par les exercices physiques (méthodes)</term>
<term>État de santé (MeSH)</term>
<term>Études multicentriques comme sujet (MeSH)</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Exercise Therapy</term>
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<term>Myasthenia Gravis</term>
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</keywords>
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</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Exercise Tolerance</term>
<term>Female</term>
<term>Health Status</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multicenter Studies as Topic</term>
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<term>Physical Fitness</term>
<term>Quality of Life</term>
<term>Randomized Controlled Trials as Topic</term>
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<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Aptitude physique</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>France</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mesures des résultats rapportés par les patients</term>
<term>Mâle</term>
<term>Méthode en simple aveugle</term>
<term>Qualité de vie</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tolérance à l'effort</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Research exploring the effects of physical exercise in auto-immune myasthenia gravis (MG) is scarce. The few existing studies present methodological shortcomings limiting the conclusions and generalisability of results. It is hypothesised that exercise could have positive physical, psychological as well as immunomodulatory effects and may be a beneficial addition to current pharmacological management of this chronic disease. The aim of this study is to evaluate the benefits on perceived quality of life (QOL) and physical fitness of a home-based physical exercise program compared to usual care, for patients with stabilised, generalised auto-immune MG.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>MGEX is a multi-centre, interventional, randomised, single-blind, two-arm parallel group, controlled trial. Forty-two patients will be recruited, aged 18-70 years. Following a three-month observation period, patients will be randomised into a control or experimental group. The experimental group will undertake a 40-min home-based physical exercise program using a rowing machine, three times a week for three months, as an add-on to usual care. The control group will receive usual care with no additional treatment. All patients will be followed up for a further three months. The primary outcome is the mean change in MGQOL-15-F score between three and six months (i.e. pre-intervention and immediately post-intervention periods). The MGQOL-15-F is an MG-specific patient-reported QOL questionnaire. Secondary outcomes include the evaluation of deficits and functional limitations via MG-specific clinical scores (Myasthenia Muscle Score and MG-Activities of Daily Living scale), muscle force and fatigue, respiratory function, free-living physical activity as well as evaluations of anxiety, depression, self-esteem and overall QOL with the WHO-QOL BREF questionnaire. Exercise workload will be assessed as well as multiple safety measures (ECG, biological markers, medication type and dosage and any disease exacerbation or crisis).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DISCUSSION</b>
</p>
<p>This is the largest randomised controlled trial to date evaluating the benefits and tolerance of physical exercise in this patient population. The comprehensive evaluations using standardised outcome measures should provide much awaited information for both patients and the scientific community. This study is ongoing.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b>
</p>
<p>ClinicalTrials.gov, NCT02066519 . Registered on 13 January 2014.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29347991</PMID>
<DateCompleted><Year>2019</Year>
<Month>03</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>03</Month>
<Day>29</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1745-6215</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>Jan</Month>
<Day>18</Day>
</PubDate>
</JournalIssue>
<Title>Trials</Title>
<ISOAbbreviation>Trials</ISOAbbreviation>
</Journal>
<ArticleTitle>The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.</ArticleTitle>
<Pagination><MedlinePgn>49</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13063-017-2433-2</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Research exploring the effects of physical exercise in auto-immune myasthenia gravis (MG) is scarce. The few existing studies present methodological shortcomings limiting the conclusions and generalisability of results. It is hypothesised that exercise could have positive physical, psychological as well as immunomodulatory effects and may be a beneficial addition to current pharmacological management of this chronic disease. The aim of this study is to evaluate the benefits on perceived quality of life (QOL) and physical fitness of a home-based physical exercise program compared to usual care, for patients with stabilised, generalised auto-immune MG.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">MGEX is a multi-centre, interventional, randomised, single-blind, two-arm parallel group, controlled trial. Forty-two patients will be recruited, aged 18-70 years. Following a three-month observation period, patients will be randomised into a control or experimental group. The experimental group will undertake a 40-min home-based physical exercise program using a rowing machine, three times a week for three months, as an add-on to usual care. The control group will receive usual care with no additional treatment. All patients will be followed up for a further three months. The primary outcome is the mean change in MGQOL-15-F score between three and six months (i.e. pre-intervention and immediately post-intervention periods). The MGQOL-15-F is an MG-specific patient-reported QOL questionnaire. Secondary outcomes include the evaluation of deficits and functional limitations via MG-specific clinical scores (Myasthenia Muscle Score and MG-Activities of Daily Living scale), muscle force and fatigue, respiratory function, free-living physical activity as well as evaluations of anxiety, depression, self-esteem and overall QOL with the WHO-QOL BREF questionnaire. Exercise workload will be assessed as well as multiple safety measures (ECG, biological markers, medication type and dosage and any disease exacerbation or crisis).</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This is the largest randomised controlled trial to date evaluating the benefits and tolerance of physical exercise in this patient population. The comprehensive evaluations using standardised outcome measures should provide much awaited information for both patients and the scientific community. This study is ongoing.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov, NCT02066519 . Registered on 13 January 2014.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Birnbaum</LastName>
<ForeName>Simone</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Bioingénierie, Tissus et Neuroplasticité (BIOTN) EA 7377, University Paris-Est, UPEC, Créteil, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hogrel</LastName>
<ForeName>Jean-Yves</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Porcher</LastName>
<ForeName>Raphael</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS-UMR1153), Hôtel-Dieu, AP-HP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Portero</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Bioingénierie, Tissus et Neuroplasticité (BIOTN) EA 7377, University Paris-Est, UPEC, Créteil, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Rothschild Hospital, AP-HP, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clair</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Raymond Poincaré Hospital, AP-HP, Garches, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eymard</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Demeret</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Neurological Intensive Care Unit, Pitié-Salpêtrière Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bassez</LastName>
<ForeName>Guillaume</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gargiulo</LastName>
<ForeName>Marcela</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Myology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.</Affiliation>
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<ArticleIdList><ArticleId IdType="pubmed">29347991</ArticleId>
<ArticleId IdType="doi">10.1186/s13063-017-2433-2</ArticleId>
<ArticleId IdType="pii">10.1186/s13063-017-2433-2</ArticleId>
<ArticleId IdType="pmc">PMC5774148</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>BMJ. 2013 Jan 08;346:e7586</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23303884</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 2003 Sep;998:445-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14592913</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2000 Dec;32(12):1975-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11128838</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2008 Feb;37(2):141-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18059039</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Phys Med Rehabil. 2012 Aug;91(8):725-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22311063</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Croat Med J. 2009 Apr;50(2):105-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19399942</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurol. 2000 Apr;247(4):286-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10836621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Phys Med Rehabil. 2015 Jul;96(7):1329-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25596001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Neurol. 2014 Nov;34(5):542-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25520026</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mult Scler. 2008 Jan;14(1):129-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17881388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Autoimmun. 2014 Feb-Mar;48-49:143-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24530233</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12091180</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuroepidemiology. 2010;34(3):171-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20130418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Musculoskelet Disord. 2015 Jun 10;16:139</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26055647</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Consult Clin Psychol. 1969 Aug;33(4):430-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">5810587</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2011 Jan;43(1):14-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21082698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 1999 Apr 22;52(7):1487-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10227640</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMJ. 2016 Aug 09;354:i3857</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27510511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Qual Life Res. 2004 Mar;13(2):299-310</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15085902</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12186831</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9881538</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2001 Apr;24(4):512-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11268023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Encephale. 1986 Mar-Apr;12(2):77-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3743520</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neurosci Nurs. 1998 Jun;30(3):191-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9689611</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Clin Nutr. 1983 Mar;37(3):461-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6829488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Intern Med. 2008 Feb 19;148(4):295-309</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18283207</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Sports Med. 2017 Apr;51(8):640-644</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27993842</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2017 May;55(5):639-645</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27533497</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Neurophysiol. 2008 Jan;119(1):2-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18039594</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Surg. 2012;10(1):28-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22036893</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2005 Aug;26(2):319-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16055882</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ISRN Cardiol. 2012;2012:718789</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23198160</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurol Sci. 2001 Oct;22(5):363-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11917973</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2017 Aug;56(2):207-214</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27935072</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Encephale. 2000 Sep-Oct;26(5):13-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11192800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phys Ther. 2016 Oct;96(10 ):1514-1524</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27149962</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Leukoc Biol. 2008 Nov;84(5):1271-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18664531</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Phys Med Rehabil. 1993 Nov;74(11):1178-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8239958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Care. 2003 Aug;48(8):783-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12890299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2007 Jun 5;68(23):2003-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17548549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Phys Med Rehabil. 2007 Nov;88(11):1452-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17964887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Sports Med. 2015 Nov;49(21):1414-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26476429</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2009 Apr;41(4):810-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19276852</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Med Sci Sports Exerc. 2001 Jun;33(6):869-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11404649</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Health Qual Life Outcomes. 2010 Nov 11;8:129</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21070628</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Muscle Nerve. 2017 Oct;56(4):700-709</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28085204</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurology. 2000 Jul 12;55(1):16-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10891897</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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<name sortKey="Portero, Pierre" sort="Portero, Pierre" uniqKey="Portero P" first="Pierre" last="Portero">Pierre Portero</name>
<name sortKey="Portero, Pierre" sort="Portero, Pierre" uniqKey="Portero P" first="Pierre" last="Portero">Pierre Portero</name>
<name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name>
<name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name>
<name sortKey="Sharshar, Tarek" sort="Sharshar, Tarek" uniqKey="Sharshar T" first="Tarek" last="Sharshar">Tarek Sharshar</name>
<name sortKey="Thoumie, Philippe" sort="Thoumie, Philippe" uniqKey="Thoumie P" first="Philippe" last="Thoumie">Philippe Thoumie</name>
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   |texte=   The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.
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The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.

The benefits and tolerance of exercise in myasthenia gravis (MGEX): study protocol for a randomised controlled trial.

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